Invited News & Views article for Nature Biomedical Engineering

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Richard Bruch, Prof. Gerald A. Urban and Dr. Can Dincer were invited to write a News & Views for Nature Biomedical Engineering, on the article "Detection of unamplified target genes via CRISPR–Cas9 immobilized on a graphene field-effect transistor".

The research article by Kiana Aran and colleagues, currently one of the most-viewed article in Nature Biomedical Engineering, presents a novel electrical biosensor, termed "CRISPR-Chip", for the rapid detection of gene mutations in purified samples without any nucleic acid amplification. The CRISPR-Chip combines the advantages of graphene field-effect transistors with those of the CRISPR/Cas technology. The target nucleic acid sequence is scanned within the whole genome and detected by the highly specific binding to the immobilized and catalytically inactive Cas9.

The News & Views "Unamplified gene sensing via graphene-bound Cas9", published in the June issue of Nature Biomedical Engineering, provides a better insight to the article of Aran and colleagues, and gives an overview about the achievements of the CRISPR-Chip. Besides, Can Dincer and coworkers provide their expert view on this work, discussing its impact, limitations, and future opportunities.

The article can be accessed under: R. Bruch, G.A. Urban and C. Dincer, "Unamplified gene detection via graphene-bound Cas9", Nature Biomedical Engineering, 2019, 3, 419-420.

Contact
Dr. Can Dincer
Laboratory for Sensors
Department of Microsystems Engineering – IMTEK &
Freiburg Center for Interactive Materials and Bioinspired Technologies – FIT
phone: +49 761 203 7264
email: dincer@imtek.de

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